Chemistry at EMBL
Biochemical and chemical approaches to biomolecular networks
Biological or cellular functions emerge from networks of interacting molecules. We develop and apply (bio)chemical strategies to chart interactions between biomolecules on a large-scale. One of our recent focus concerns the development of metabolite arrays and the integration of biochemical protein purification and mass spectrometry to study interactions between proteins and small molecule metabolites.
Selected publications:
The social network of a cell: recent advances in interactome mapping. Charbonnier S., Gallego O. and Gavin A.C. (2008). Biotechnol Annu Rev 14, 1-28.
Proteome survey reveals modularity of the yeast cell machinery. Gavin A.C., Aloy P., Grandi P., Krause R., Boesche M., Marzioch M., Rau C., Jensen L.J., Bastuck S., Dümpelfeld B., Edelmann A., Heurtier M.A., Hoffman V., Hoefert C., Klein K., Hudak M., Michon A.M., Schelder M., Schirle M., Remor M., Rudi T., Hooper S., Bauer A., Bouwmeester T., Casari G., Drewes G., Neubauer G., Rick J.M., Kuster B., Bork P., Russell R.B. and Superti-Furga G. (2006). Nature 440, 631-636.
Structure-based assembly of protein complexes in yeast. Aloy P., Böttcher B., Ceulemans H., Leutwein C., Mellwig C., Fischer S., Gavin A.C., Bork P., Superti-Furga G., Serrano L. and Russell R.B. (2004). Science 303, 2026-2029.