Instrumentation at the EMBL Grenoble outstation

At the EMBL Grenoble, the Diffraction Instrumentation Team develops instruments for Macromolecular X-ray crystallography, neutron crystallography and Small Angle X-ray Scattering experiments, strongly involving the Synchrotron Crystallography and High Throughput Crystallisation teams. Current focus is on beamline automation, diffractometers for micro-crystals and automation of crystal harvesting. Several projects are developed in collaboration with the ESRF Structural Biology Group and with EMBL@PETRA-III. Most of the instruments developed are commercially available from Bruker-asc, Maatel scientific-instrumentation, Cedrat, Molecular Dimensions, Hampton Research or Mitegen.

Contact: Instrumentation




On the workbench
MD3-icon MD3 vertical Kappa Diffractometer
In collaboration with EMBL@PETRA-III MX2 beamline, Gleb Bourenkov.
Download the video "MD3_SOC-1" - Kappa = 0°, Omega 160°/s; Glass needle 0.3 µm tip; Scale 1 µm/div
Download the video "MD3_SOC-2" - Kappa = 48°, Omega 20°/sec; Glass needle 1 µm hole; Scale 10 µm/div
Download the video "MD3_4Dscan" - Needle Ø8 µm X 150 µm; 4D scan: 180°, 18°/s; Scale 10 µm/div

BioSAXS-SE-icon
CrystalDirect
Jointly with the Grenoble HTX Team, J.A. Marquez
In-plate crystal screening & automated harvesting
Download the video "CD_LaserHarvesting"
NewPin
NewPin
Supported by BioStruct-X
Tentative for a new European sample holder standard
Download the video "Repositioning precision"


Instruments for Macromolecular X-ray crystallography and SAXS experiments
BioSAXS-SE-icon BioSAXS automated sample environment
HC1_icon
HC1 Crystal Humidity Control
ESRF, Diamond, MAX-Lab, Bessy, CLS
Collaboration link
sc3 Sample Changer SC3, download a video load/unload 1 sample (real time)  4.3 Mb
ESRF  ID14-1, ID14-2, ID14-3, ID14-4, ID29, ID23-1, ID23-2 ; embl-France  ESRF BM14 CRG
MiniKappa Mini Kappa Goniometer Head, download videos
ESRF  ID14-4, ID29, ID23-1; embl-France  ESRF BM14 CRG, ESRF BM30 CEA-IBS CRG, APS  LS CAT; Diamond; ALS; Bessy
Microspectrophotometer,
ESRF ID14-x
Use it at the ESRF
md2m MD2M Diffractometer (Minidiffractometer)
ESRF  ID14-1, ID14-2, ID14-4, ID29, ID23-1, ID23-2
md2 MD2 Diffractometer (Microdiffractometer)
SLS  X06S; ESRF  ID14-3; embl-France  ESRF BM14 CRG; APS NE CAT, LS CAT; Bessy, ALS, CLS, SSRL, EMBL-HH, Alba, MAX-lab, Soleil
auto_centring results Automatic Crystal Alignment Library C3D
ESRF  ID14-1, ID14-2, ID14-3, ID14-4, ID29, ID23-1, ID23-2 ; EMBL/ESRF BM14 (CRG); NSLS
OAV On Axis Video-microscope
ESRF BM30  FIP CNRS/IBS GRG + EMBL/ESRF BM14 (CRG); NSLS
Piezoelectric_Shutter Piezoelectric Shutter, download a video 1" exposure 5 passes ( real time 5 x 0.2")  215Kb
ESRF  ID14-1, ID14-2, ID14-3, ID14-4, ID29, ID23-1, ID23-2; APS NE-CAT, EMBL-HH
md1
                                                                                                                                                              
Neutron diffractometers
vivaldi FINDER (VIVALDI)
ILL VIVALDI, LADI3; ANSTO (KOALA); FRMII (QLD); Oak Ridge National Lab (LADI-III)